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In
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pregnant women, poor folate intake can result to the infant growth retardation, macrocytic anaemia, GI disorders, glossitis and neural tube defects. Prescription medications
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that can interact with folate include the following. Failure of the body to absorb folic acid can result to conditions like Crohn disease or ulcerative colitis. It also maintains the proper balance and synthesis of neurotransmitters in the nervous system.

Red blood cell production and support for circulation. Children aged 1-3 years old need 150 mg/day; children aged 4-8 years are required to prescription drugs without insurance 19 years and up need 400 mg/day of folate. Infants from birth to 6 months need 65 mg/day of folate; infants 7-12 months require 80 mg/day.

Deficiency Symptoms in Adults and Children Since folate is related to nervous system functions, insufficient folate levels can result in irritability,
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forgetfulness, mental fatigue, depression, confusion and insomnia. Weakness and fatigue Feeling of light-headedness Forgetfulness Irritability Pale appearance Weight loss and lack of appetite Difficulty to focus and concentrate Recommended Daily Intake of Folate Recommended daily intake of folic acid
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is dependent on particular age and gender groups. It is essential that patients would inform their doctors if they are taking these medications. It also aids
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in the prevention of anaemia. Folic acid also helps in the maintenance of healthy blood circulation by preventing the build-up of homocysteine. Certain conditions arise when there is folic acid deficiency like periodontal disease, seborrhoea dermatitis and cancer. Since it has a complex structure, it also has a rather complicated interaction with the human body. In connection with circulatory functions, deficient folate can cause general or muscular fatigue. Abdominal pain and diarrhoea Tongue sores Chapped lips especially around the corners of the mouth Shortness of breath with activity and exertion
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Chest pains with rapid and irregular heart rate As the deficiency progresses, it would lead to com symptoms of anaemia which may include. In addition, folate can also be used in adjunct treatments to enhance the response to antidepressants. Mothers with folate deficiency tend to give birth to infants with
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neural tube defects, often
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resulting in brain and spinal luce disorders such as spina bifida. As the insufficiency of folate increases, certain symptoms of anaemia may develop. Folic Acid Food Sources Excellent sources of folate include green leafy vegetables such as romaine lettuce, spinach, asparagus, turnip greens, mustard greens, beans, peas and lentils, Brussels sprouts, broccoli, beets, parsley and collard greens.
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Pregnant women obviously need a greater amount of folate intake in consideration with foetal development. Functions of Folic Acid Several functions of folic acid in the body include. Cell production especially in the skin. Anticonvulsant-induced folate deficiency Cancers of the colon, pancreas and cervix Drug-induced toxicity End stage renal disease or ESRD Folate deficiency Hyperhomocysteinemia Megaloblastic anaemia Prevention of neural tube defects Phenytoin-induced gingival hyperplasia Pregnancy-related gingivitis Drug Interactions with Folic Acid Certain types of prescription drugs can deplete the body folate supply.

Poultry, calf liver, wheat germ, nutritional yeast, tuna, mushrooms, and fruits like oranges, bananas, strawberries and cantaloupes are also good sources of folic acid. These defects often involve the malformation of the neural tube, which is responsible for the development of the baby brain and spinal rabbi. Anti-cancer medications such as methotrexate Cholesterol-lowering drugs like cholestyramine Anti-inflammatory drugs like sulfasalazine Biguanide drugs like buformin, phenformin and metformin used for diabetes treatment Birth control pills (oral contraceptives) Potassium-sparing diuretics such as triamterene Antibiotics such as trimethoprim
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and pyrimethamine. Mild folic acid anaemia may have no symptoms at all. Folic acid is now also added to bread and grain products to encourage folate intake and decrease the prevalence of neural tube defects. Less com symptoms may include the following. Lack of folate intake can also cause problems in the intestinal tract like diarrhoea and oral conditions like gingivitis and periodontal disease. It is a B-complex water-soluble vitamin that can be naturally found in food sources and supplements. There are food sources that do not have folic acid, and body enzymes in the intestines have to chemically alter these food substances to form folate. An increased intake of folic acid in men has been suggested to lower the risk of cardiovascular disease. Requirement for Increased Amounts of Folic Acid Pregnant adult women and breastfeeding mothers are usually given an increased amount of folate to prevent birth defects in infants.
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Prevention of nervous system disorders. Folic Acid Introduction Folic acid is also known as vitamin M, folate or folacin. Folic acid allows nerves to function normally. Other conditions that require increased folate amounts include. In pregnant women, folate intake of 600 mg/day is recommended whilst lactating mothers would need 500 mg/day of folate. Studies have also linked folate deficiency and high homocysteine levels with coronary heart disease, cerebral vascular disease and peripheral vascular diseases. It is popular for its essential role in pregnancy and prevention of birth defects. There are three main components of folic acid namely PABA, glutamic acid and pteridine.

Skin, intestinal, and cells that line the body cavities have a minimal life span and are dependent on folic acid for their production.



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